Solublizing nasty peptide
RNeubig at umich.edu
Mon Mar 20 16:23:10 EST 1995
I have been trying to solublize a particularly nasty 33-mer
peptide which is moderately hydrophobic.
I can get it into DMSO or acetonitrile but it forms an opalescent
suspension when I try to dilute into aqueous solutions (at either
1 mM or slightly less). Any suggestions about how to get it into
solution with some semblence of a "native" conformation -
which is the aim of the work.
Thanks in advance,
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