Identifying protein domains
harper at ebi.ac.uk
Fri Mar 24 07:13:12 EST 1995
In article <1995Mar24.103744.1 at molbiol.ox.ac.uk>, jsinclair at molbiol.ox.ac.uk writes:
>Is anyone aware of any e-mail/www servers which predict possible domains
>within a protein? And are there any useful experimental techniques that can be
>employed other than looking for fragments generated in proteolytic digests?
>Thanks for any suggestions.
>John Sinclair (JSINCLAIR at MOLBIOL.OX.AC.UK)
Have a look at:
The ProDom protein domain database:
ProDom is a comprehensive collection of protein families, constructed
by clustering all complete protein seuqences in Swiss-prot. by the
clustering algorithm Domainer, developed by Sonnhammer and Kahn.
The novelty of ProDom is that the modular arrangement of proteins
have been taken into account and whenever domain boundaries were
detected the sequences were cut to produce consistent families of domains.
R. Andrew Harper E-mail: harper at ebi.ac.uk
EMBL Outstation - The EBI URL: http://www.ebi.ac.uk
Hinxton Hall, Hinxton, Telephone: +44 (0)223 494 429
Cambridge CB10 1RQ U.K. Fax: +44 (0)223 494 468
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