Identifying protein domains

[Rob Harper]

In article <1995Mar24.103744.1 at molbiol.ox.ac.uk>, jsinclair at molbiol.ox.ac.uk writes:
>Is anyone aware of any e-mail/www servers which predict possible domains 
>within a protein? And are there any useful experimental techniques that can be 
>employed other than looking for fragments generated in proteolytic digests?
>
>Thanks for any suggestions.
>
>John Sinclair (JSINCLAIR at MOLBIOL.OX.AC.UK)
>
Have a look at:

The ProDom protein domain database: 

URL http://www.sanger.ac.uk/~esr/prodom.html

ProDom is a comprehensive collection of protein families, constructed 
by clustering all complete protein seuqences in Swiss-prot. by the 
clustering algorithm Domainer, developed by Sonnhammer and Kahn. 
The novelty of ProDom is that the modular arrangement of proteins 
have been taken into account and whenever domain boundaries were 
detected the sequences were cut to produce consistent families of domains. 


-- 
 R. Andrew Harper                   E-mail:    harper at ebi.ac.uk
 EMBL Outstation - The EBI          URL:       http://www.ebi.ac.uk
 Hinxton Hall, Hinxton,             Telephone: +44 (0)223 494 429
 Cambridge CB10 1RQ U.K.            Fax:       +44 (0)223 494 468