BSE - prion heat resistance

Oz Oz at upthorpe.demon.co.uk
Mon Apr 1 12:03:51 EST 1996


In article <4jnddd$jpn at agate.berkeley.edu>, Louis Hom
<lhom at nature.berkeley.edu> writes
>In article <316013A3.2F52 at nzdri.org.nz>,
>Grant Boston  <grant.boston at nzdri.org.nz> wrote:
>>the prion protein has been shown to be stable under 340 C dry heat for 1 
>>hour, 140 C autoclave for 1 hour, and 130 C dry heat for 12 hours!!! An 
>>amazingly strong protein especially as it's mode of action seems to 
>>depend on the tertiary structure.
>
>It seems odd to me that they would focus so much on stability in dry
>conditions.  

Perhaps because of heating during the pelleting process (for M&B meal).
Perhaps to see what incineration conditions are appropriate.

Dunno. 

It certainly makes a DNA/RNA basis for the disease problematical, I
would have thought.

------------------------------- 
'Oz     "When I knew little, all was certain. The more I learnt,
        the less sure I was. Is this the uncertainty principle?"



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