International Conference on Protein Folding and Design at NIH

Peter Munson munson at HELIX.NIH.GOV
Fri Jan 26 17:54:07 EST 1996


International Conference on

April 23-26, 1996

Natcher Conference Center
National Institutes of Health
Bethesda, Maryland, USA

Dedicated to the life and work of
Christian B. Anfinsen, 1916-1995

Fogarty International Center
National Cancer Institute
Division of Computer Research and Technology, NIH
National Center for Biotechnology Information, NLM
National Institute of Child Health and Human Development
National Institute of Diabetes and Digestive and Kidney Diseases

Registration:  There is no registration fee.  Interested parties may
register by sending their name, institution, telephone, fax and e-mail
address to feldmans at by April 9.

Posters:  Persons outside the NIH interested in presenting a poster are
invited to send a 150-200 word abstract to feldmans at by
February 15.  They will be notified of their acceptance by February 23.  NIH
scientists may submit abstracts by March 15 and will be notified of
acceptance by March 23.

For more information contact Sheila Feldman; tel. 301-496-2968, fax
301-496-8496; e-mail feldmans at  Also, see the NIH home
page (news and events) for updates:

Program Committee:
Jean Garnier, Fogarty Scholar-in-Residence, DCRT, NIDDK
   National Institute of Agronomic Research
    Jouy-en-Josas, France
David Rodbard,  Division of Computer Research and Technology, NIH
Byungkook Lee,  National Cancer Institute
Robert Hartley,  National Institute of Diabetes and Digestive and Kidney

On April 22, former friends and colleagues of Dr. Anfinsen will hold
a memorial service in his honor from 3 to 5 PM, in Wilson Hall, Bldg 1.


Tuesday, April 23

 8:00  Registration
 9:00  Welcome     Philip Schambra
 9:05  Introductory remarks     Jean Garnier
 9:10  Tribute to Christian B. Anfinsen   Frederic Richards

Session 1: Protein Folding: In vitro
             (Chair: Frederic Richards)
 9:20 Janet Thornton - Protein fold families
 9:50 Brian Matthews - T4 lysozyme: Folding and function
10:20 Alan Fersht - Nucleation mechanisms in folding
11:10 Chris Dobson - Following folding by NMR
11:40 Robert Sauer - Determinants of protein folding: Lessons from
       random and multiply-mutant sequences

Session 2: Protein Folding: In vivo
            (Chair: David Davies)
 2:00 F. Ulrich Hartl - Pathways and mechanisms of chaperone-mediated
                          protein folding
 2:30 George Lorimer - Chaperonin ATP-ase cycles
 3:00 Paul Sigler - Structural insight into the function of GroEL
                        and its liganded states
 3:50 Ari Helenius - Glycoprotein folding in the endoplasmic reticulum
 4:20 Rainer Jaenicke - Protein folding and association in vitro versus in vivo

Wednesday, April 24

Session 3: Protein Design
              (Chair: Angela Gronenborn)
 9:00 Jane Richardson - The problem of unique versus approximate structures
          in protein design
 9:30 William DeGrado - De novo design of helical proteins
10:00 Barry Robson - Novel proteins: Automated design and automated synthesis
10:50 Michael Hecht - A binary code for de novo protein design: Novel proteins
                        by the dozen
11:20 Manfred Mutter - Non-natural architecture in protein design

Session 4: Protein Design (Continued)
              (Chair: Jonathan Greer)
1:30 Lynne Regan - The design of metal binding sites in proteins
2:00 Elizabeth Getzoff - Site-directed mutagenesis and catalytic antibodies
2:30 Howard Schachman - Assembly of proteins from circularly permuted
     and fragmented polypeptides: Model studies with aspartate transcarbamylase

Thursday, April 25

Session 5: Design of Protein Therapeutic Agents:

                      Antibody Engineering (Chair: Paul Carter)
 9:00 Andreas Pluckthun - Improved antibody framework
 9:30 Edgar Haber - Antibody-targeted plasminogen activators
10:00 Arne Skerra - De novo design of an antibody: Modeling,
             bacterial expression, and crystallographic analyses

                      Hybrid Proteins (Chair: Byungkook Lee)
10:50 Ira Pastan - Hybrid proteins as therapeutics
11:20 David Segal - Targeting of cytotoxic cells with recombinant
                        bispecific molecules
11:50 Maurice Hofnung - Chimeric bacterial proteins: Permissive sites
                           and indels
12:20 Patrice Boquet - Chimeric toxins derived from diphtheria toxin:
                        Therapeutic and cell biology utilizations

 Session 6: Theory of Protein Folding
              (Chair: Joseph Bryngelson)
 2:30 Martin Karplus - Protein folding: some insights from simulation
 3:00 Peter Wolynes - The energy landscape theory of protein folding
 3:30 Eugene Shakhnovich - Nucleation mechanism of protein folding and its
                            implications for evolution and design
 4:20 Harold Scheraga - The multiple-minima problem in protein folding

Friday, April 26

Session 7: Prediction of Protein Structure
              (Chair: Shoshana Wodak)
 9:00 Jean Garnier -  Predictions: A challenge
 9:30 Chris Sander - Protein structure: 1D to 3D
10:00 Manfred Sippl - Progress in fold recognition: From genome sequences
                           to protein structures
10:50 Tim Hubbard - Structure prediction using hidden Markov models
                      and beta-strand pair potentials
11:20 Stephen Bryant - Choosing the right fold: An alignment model
                          for protein threading

Session 8: Computer Simulations
              (Chair: Arnold Hagler)
 1:30 George Rose - Linus: A hierarchic procedure to predict the fold
                              of a protein
 2:00 Ken Dill - Simple models of protein folding
 2:50 Nobuhiro Go - Dynamic properties of protein by normal mode
                             and principal component analyses
 3:20 Henri Orland - Monte Carlo growth method for modeling peptides

 3:50        Concluding Remarks

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