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Isoelectric Points

RAB rab at oci.utoronto.ca
Mon Mar 18 10:47:22 EST 1996

Bob Hoesch wrote:
> What kinds of calculations and what sorts of parameters need to be taken into
> consideration in trying to answer the following questions?---
> 1) What is the largest theoretical isoelectric point shift due to a single AA
> substitution?  (Does anyone know of any observed measurements?)

One example I worked with, the removal of a C-terminal Lysine from pae 
lectin results in a pI shift from 7.2 to 6.1


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