Acetylcholinesterase (AChE) can be inhibited with
diisopropylfluorophosphate (DFP). Howver, the inhibited enzyme can be
reactivated with oximes or hydroxamic acid derivatives. In our lab we
would like to reactivate a different (parasitic) esterase, which has been
inhibited with DFP. However, most of the reactivators described in the
literature do not seem to be available from the usual suppliers.
Can anybody point us to any of the following compounds (commercial
availability, a kind gift or an easy synthetic approach):
- P2S (1-methyl-2-hydroxyiminomethylpyridinium methane sulfonate)
- N-phenylnicotinohydroxamic acid
- formhydroxamic acid
Please send an email to Dundee and/or answer to this newsgroup.
Dept. Biochemistry Tel. +44-1382-344301
University of Dundee fax +44-1382-322583
Dundee DD1 4HN
Scotland, UK email a.treumann at dundee.ac.uk