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Acetylcholinesterase (AChE) regeneration after DFP?

T. Chyau Liang tliang at utmmg.med.uth.tmc.edu
Tue Mar 19 11:28:28 EST 1996

Hydroxyiminoacetone should be easy to prepare from hydroxylamine HCl and
acetone. See a related procedure in J.Org. Chem. 55(12), p 3740 (synthesis
of compound 9), 1990. Any hydroximate functional group can be easily
followed on TLC with ferric chloride, which gives a pink-brown stain.

Good luck,

T. Chyau Liang, Ph.D.
U. Texas-Houston

> Can anybody point us to any of the following compounds (commercial 
> availability, a kind gift or an easy synthetic approach):
> - P2S (1-methyl-2-hydroxyiminomethylpyridinium methane sulfonate)
> - hydroxyiminoacetone
> - N-phenylnicotinohydroxamic acid
> - formhydroxamic acid

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