BSE - prion heat resistance

Louis Hom lhom at
Sun Mar 31 21:01:17 EST 1996

In article <316013A3.2F52 at>,
Grant Boston  < at> wrote:
>the prion protein has been shown to be stable under 340 C dry heat for 1 
>hour, 140 C autoclave for 1 hour, and 130 C dry heat for 12 hours!!! An 
>amazingly strong protein especially as it's mode of action seems to 
>depend on the tertiary structure.

It seems odd to me that they would focus so much on stability in dry
conditions.  I would expect denaturation to be much more pronounced (and
relevant) in the presence of solvent (don't we lyophilize a lot of enzymes
for added stability?). 
Lou Hom >K '93		       	 	  
lhom at 

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