Product binding sites on proteins
bcg0197 at queens-belfast.ac.uk
Tue May 14 05:57:36 EST 1996
In article <4m5n63$73q at news.duke.edu>, tschantz at galactose.mc.duke.edu (William P. Tschantz) writes:
> I am looking for examples of proteins which have two product binding
> sites (the same product) if such a protein exists. For example a protein
> which has one binding site where the product is formed and then is
> transferred to a second site on the enzyme. I know this sounds kind of
> weird but i am trying to make sense of the data i have. The only way i
> can explain it is if there is a second site present on the enzyme. I can
> think of no examples except for ribosomes, which is not quite what i am
> looking for.
> Any help is greatly appreciated.
I'm not an enzymologist but as far as I remember the enzymes
involved in fatty acid metabolism do something of this kind.
Also, the plant/bacterial enzymes involved in carbon and
nitrogen fixation might be other examples worth considering.
Have a look in a biochemistry textbook such as Stryer or
Lehninger, or Alan Fersht's book Enzyme Structure and
Mechanism, you will probably find what you're looking for.
Hope this helps you.
Andrew Wallace, Ph.D.
School of Biology and Biochemistry
The Queen's University of Belfast
97 Lisburn Road Tel. +44-1232-335786
Belfast BT9 7BL Fax +44-1232-236505
Northern Ireland (UK) a.wallace at queens-belfast.ac.uk
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