Product binding sites on proteins

[Andrew Wallace]

In article <4m5n63$73q at news.duke.edu>, tschantz at galactose.mc.duke.edu (William P. Tschantz) writes:
> Hi
> 
> I am looking for examples of proteins which have two product binding 
> sites (the same product) if such a protein exists.  For example a protein 
> which has one binding site where the product is formed and then is 
> transferred to a second site on the enzyme.  I know this sounds kind of 
> weird but i am trying to make sense of the data i have.  The only way i 
> can explain it is if there is a second site present on the enzyme.  I can 
> think of no examples except for ribosomes, which is not quite what i am 
> looking for. 
> 
> Any help is greatly appreciated.
> 
> Thanks 
> 
> Bill

      I'm not an enzymologist but as far as I remember the enzymes
      involved in fatty acid metabolism do something of this kind.
      Also, the plant/bacterial enzymes involved in carbon and
      nitrogen fixation might be other examples worth considering.
      Have a look in a biochemistry textbook such as Stryer or
      Lehninger, or Alan Fersht's book Enzyme Structure and
      Mechanism, you will probably find what you're looking for.

      Hope this helps you.

      Andrew
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      Andrew Wallace, Ph.D.
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