Anyone know a protein with real low pI ?
steipe at LMB.uni-muenchen.de
Thu Nov 14 04:01:56 EST 1996
Deirdre O'Sullivan wrote:
> I am looking for a protein of pI less than 3, which is NOT pepsin or an
> acidic protease. Other desirable qualities include fairly low molecular
> weight and it should be easily obtainable.
A search on Expasy <http://expasy.hcuge.ch/www/guess-prot.html> returns
only two proteins with a pI below 3 - and they don't exactly meet your
2 proteins found
pI: 2.15, MW: 37141.05
pI: 2.91, MW: 4443.52
GENE 40 PROTEIN (GP40).
Actually with pKs of carboxyl groups being not lower than 3.9 and at
least one positive charge (on the N-terminus) this is not surprising.
677 proteins with a pK below 4 in Swissprot though. A number of
ferredoxins have pIs below 3.3.
+---Dr. Boris Steipe------------<steipe at LMB.uni-muenchen.de>---+
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