Proteins in Alzheimer's
Marc.Saric at rz.ruhr-uni-bochum.de
Sun Nov 2 08:48:17 EST 1997
NewNovels at aol.com wrote:
> A few years ago in my graduate class in Advances in Neurobiology and
> Behavior, One of my classmates reported a paper in Alzheimer's disease. I
> could not recall the exact problem in that paper but i remembered i made a
> conclusion which is this:
> "A change in the secondary/tertiary structure of a protein would
> attract/require a different reactant/enzyme(s) thus producing
> (directly/indirectly) the so called plaques".
> I never followed this up but sometimes i am just bothered about this, and i
> want it cleared. Was the mutation in the genetic or the protein level?
I think this is still unclear. For BSE and CJD the "prion-hypothesis"
suggests a change on the protein-level. Despite the fact that Stanley
Prusiner got the Nobel-prize for this hypothesis, it hasn´t been proved
to full extent until now.
More information about the Proteins