Domains with more than one function

David Micklem drm21 at
Mon Nov 3 16:10:59 EST 1997


I was hoping to tap the collected wisdom to find out if there are published
examples of different members of a family of domains having different

A not-quite-perfect example would be the finding (IIRC) that some
homeodomains bind to other proteins through one 'face' of the domain, and
to DNA with another 'face'.

Ideally, I'm looking for examples of a motif (or domain) which has a well
characterised function (eg Zn-fingers and DNA binding) in most proteins,
but which has been shown to have another function (eg protein-protein
interaction) in other proteins. 

(I used the Zn-finger example because I vaguely recall hearing that this
was true of Zn-fingers - but I haven't been able to track down a

Many thanks for any assistance (and no, I'm not an student trying to cheat
on exam/essay questions!)


D.R.Micklem,                                Time flies like an arrow... 
Wellcome/CRC Institute,            Fruit flies like a banana.       
Cambridge CB2 1QR, UK               Email:drm21 at
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