Phospho-amino acids>?????

Phil Robinson phrobins at postbox.usyd.edu.au
Sun Nov 16 18:12:23 EST 1997


Mr. G. Morley wrote:

> HI.. got a bit of a duff question here.. is it only the
> phospho-tyrosine residues that can act as docking sites
> for proteins? If so does this mean that the affects of phospho
> serine and phospho threonine is entirely structural in nature?
> I was just wondering as it occured to me the other day that
> SH2 domains bind Y-p not Tp- or S-p and I could not think of anything
> which did bind these amino acids.... if anyone does know
> of an example I would greatly appreciate it...
> thanks
> gary morley
> gmorley at rpms.ac.uk

14-3-3 proteins bind to phosphoserine.  see..A. J. Muslin, J. W. Tanner,
P. M. Allen, and A. S. Shaw. Interaction of 14-3-3 with signaling
proteins is mediated by the recognition of phosphoserine. Cell
84:889-897, 1996.
There are also a few more recent papers.

Phil Robinson                        Sydney, Australia




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