dimeric receptor degradation

Mr. G. Morley gmorley at hgmp.mrc.ac.uk
Thu Sep 18 10:38:40 EST 1997


Hi... bit of a strange question...but does anyone know if
there has been any evidence (ie: papers, etc) that dimeric
tyrosine kinase cell surface receptors can be slowed in their
degredation in response to ligand by lysosoaml or ubiquitin
inhibitors. I believe quite a lot of evidence has accumulated 
suggesting that these receptors are ubiquitinated prior to degradation.
However I have not come across any reference to halting this process.
I would be very, very, very gratefull if anyone could enlighten me,
if so please e-mail me at:

	gmorley at rpms.ac.uk
Thanks in advance,
					Gary Morley.





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