Dimer and TM7

Samuel P. Lee samuel.lee at utoronto.ca
Sat Jan 24 12:30:13 EST 1998


In article <6a5men$s3c$1 at news4.isdnet.net>,
   "Christophe GUENIN" <christophe.guenin at hol.fr> wrote:
>I have a dimerisation of receptor-G protein ( 7TM-7TM and 7TM-6TM).
>Does anybody know the phenomenon ?
>Thanks to give me explanation and bibliographic references.
>Sophie
>Paris,France
>e mail : christophe.guenin at hol.fr
>

If you mean dimerization of two receptors, there many research groups 
(including our lab) that are studying this phenomenon.

It has been suspected for a long time that G protein coupled receptors may 
form dimers. In the past few years, there have been several papers that deal 
with this issue directly.

Here is a list of some publications (It is definitely not a comprehensive 
list, but, it's a start):

Maggio et al., PNAS 90: 3103, 1993
Ng et al., Biochem. Biophys. Res. Comm. 227: 200, 1996
Hebert et al., J. Biol. Chem. 271: 16384, 1996
Fukushima et al., FEBS Lett. 409: 283, 1997
Cvejic and Devi, J. Biol. Chem., 272: 26959, 1997
Nimchinsky et al., J. Biol. Chem., 272: 29229, 1997

I hope this helps.

Sam Lee
samuel.lee at utoronto.ca

Department of Pharmacology
University of Toronto
Toronto, ON, Canada
M5S 1A8



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