Ligand Binding

Marco Bocola bocola at
Thu Mar 5 12:36:00 EST 1998

Louis Hom wrote:

> Basic question:
>         Is there an activation energy associated with ligand binding?
> There has to be, right?  Since you have to displace solvent?
>         This came up after I was talking to an undergrad about basic
> enzyme behavior and the effects on the activation energy of the catalyzed
> reaction and I got to thinking about the reaction that catalyzes the
> reaction.
>         meta-reactions.
> --
> _______________________________________________________________________________
> Lou Hom >K '93
> lhom at

Don't forget about conformational changes of proteins (receptors,channels etc.)
during the binding process (induced fit !!!) which are believed to play the central
role in binding thermodynamics besides the solvation-desolvation process.

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