Signals for proteolysis

Evangelos Christodoulou echristo at biology.db.uoa.gr
Wed Aug 25 06:55:30 EST 1999


> Is there a way of finding if a certain protein is likely to be short-lived
> in a cell just by looking at the amino acid sequence? When making a
> literature search, I have found many papers that mention an "N-end rule"
> but I haven't been able to figure out what that is beyond knowing that a
> Lys residue is needed for binding of ubiquitin. Besides, I got the
> impresion that these signalling domains can be both at the N or the
> C-terminus in a protein but I don't know if they are different. By the way,
> I work in yeast, in case this makes a great difference in the way the
> proteins are processed (as you can see, I haven't got much idea about all
> these processes, sorry!)
> Could someone point me to a good www site for analysing my protein sequence
> and find if its turnover is likely to be rapid? Alternatively, anybody
> knows of a review that deals with domains in a protein that signal it for
> degradation?


http://genome.cbs.dtu.dk/services/SignalP/index.html


--
Evangelos Christodoulou
University of Athens, Greece
If Che Guevara was alive he'd use a Mac
-the only revolutionary-friendly platform



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