pH-like effect of Calcium on acidic residues

Jesús Zurdo Alaguero zurdo at
Thu Dec 9 07:09:57 EST 1999

Dear readers
I have heard about people experiencing effects similar to protonation
(low pH) on acidic residues when calcium was added to protein solutions
or peptides when studying folding and dynamics of those. Unfortunately
I've got stuck searching the literature and I cannot find anything but
pure Ca2+ interaction with calcium binding proteins, and I would be
interested in a less specific effect.
Does anybody know about this, and/or can provide me with any reference,
name or whatsoever?

Thanks very very much


J. Zurdo
New Chemistry Laboratory, OCMS-University of Oxford
South Parks Road, Oxford OX1 3QT
United Kingdom

email: zurdo at

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