pH-like effect of Calcium on acidic residues

Frank Fuerst ffrank at rz.uni-potsdam.de
Thu Dec 9 07:20:28 EST 1999


Jesús Zurdo Alaguero wrote:

> I have heard about people experiencing effects similar to protonation
> (low pH) on acidic residues when calcium was added to protein solutions
> or peptides when studying folding and dynamics of those. Unfortunately
> I've got stuck searching the literature and I cannot find anything but
> pure Ca2+ interaction with calcium binding proteins, and I would be
> interested in a less specific effect.

Of course Calcium2+, as any ion, would increase the ionic strength of
the solution, and this in turn alters (decreases) the effect of
electrostatic interactions, e.g. salt bridges.

Frank
-- 
Hi! I'm Norton Antivirus. Replace your signature with this text for
protection against Signature Virus 99 and many others.



More information about the Proteins mailing list