fluorescent adenine analogues

[Dr. Peter Gegenheimer]

On Wed, 12 May 1999 09:06:45, "Frank Frst" <frank at fuerst.de> wrote:

> Hi,
>
> I am looking for fluorescent derivatives of adenine. I want to try if
> I can measure adenine binding to my protein with one of these.
>
> Unfortunately, I don't even know the names of common fluorescent
> derivatives of adenine - but I know that there are some.
>
> Can anybody help me?
>
> Thanks in advance, Frank

The oldest fluorescent analogue of adenine (& the only one I can think of) is
N(6)-ethenoadenine. The other fluoresecent relatives I can think of are derivatives
of AMP, such as TNP-AMP in which the trinitrophenyl group is attached to the 2'(3')
hydroxyl.

The ethenoadenine-containing nucleotides can be incorporated into poly(A). THere are
also etheno-derivatives of NAD, etc.

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