Can proteinase inhibitors penetrate the cell membrane?
krasel at wpxx02.toxi.uni-wuerzburg.de
Tue Nov 16 14:28:48 EST 1999
Byung-Hoon Kim <byung-hoon.kim at uni-tuebingen.de> wrote:
> Can proteinase inhibitors (Aprotinin, Leupeptin and Pepstatin) penetrate
> the cell membrane?
Leupeptin can be used to inhibit proteolysis in lysosomes (I have seen
several publications demonstrating this), but I think that it reaches them
by endocytosis, not through permeation of the plasma membrane.
/* Cornelius Krasel, U Wuerzburg, Dept. of Pharmacology, Versbacher Str. 9 */
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