Can proteinase inhibitors penetrate the cell membrane?

Platini Kwok b965772 at
Wed Nov 17 02:56:18 EST 1999


Your consideration on solubility on cell membrane may be right. But PMSF is
quite toxic especially to cell line. So...

Nick Theodorakis ¼¶¼g©ó¤å³¹ <1415c574.a42a44e5 at>...
>In article <383175A8.3865DDA3 at>, Byung-Hoon Kim
>< at> wrote:
>> Hi, all
>> Can proteinase inhibitors (Aprotinin, Leupeptin and Pepstatin)
>> penetrate
>> the cell membrane?
>Have you thought about using small, non-peptide inhibitors like PMSF or
>TPCK? I'm not sure if either of these will penetrate the cell membrane,
>but they may be more likely to than peptide inhibitors.
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