Leucine rich protein

Paul Dalby dalby at mail.med.upenn.edu
Mon Nov 29 11:09:30 EST 1999


In article <0d58fe4a.4a4cb93b at usw-ex0103-019.remarq.com>, Thomas
<thomas.korosecNOthSPAM at univie.ac.at.invalid> wrote:

> We have sequenced a membrane protein and found an extreme
> leucine-rich region at the N-terminus. There are 14
Lÿffffc3ÿffff82ÿffffc2ÿffffb4s
> within the first 20 amino acids in clusters like
ÿffffc3ÿffffa2ÿffffe2ÿffff82ÿffffacÿffffc2ÿffffa6LLLLLPLLLÿffffc3ÿffffa2ÿffffe2ÿffff82ÿffffacÿffffc2ÿffffa6
> . Motif- and profile-searches in various databases
> (SWISSPROT, EMBL, on the Expasy Server) gave no results.
> Any idea what this motif could be?
> 
> Thanks


I can't read this sequence properly, but doesn't poly Leu form a good
transmembrane helix?  There was a paper recently in JMB by von Gunsteren
on model peptides with L12PL14 sequence.  Maybe you have found something
similar.

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