mechanism of enzyme inhibitor

George no at no.no
Wed Oct 27 18:31:45 EST 1999


I don't know whether anyone help you already or not, but one place you
look for answer to these questions are in journal articles, not text
books.  
For example, if you do subject keyword search in Medline with words
"aldolase fructose lysine", you get 16 references.  One of the
reference is titled: "Lysine-146 of rabbit muscle aldolase is essential
for cleavage and condensation of the C3-C4 bond of fructose
1,6-bis(phosphate).".  I will let you figure out the source, which
shouldn't be difficult to identify.  


Good Luck
         


In article
<9_rP3.17021$%62.260736 at c01read02-admin.service.talkway.com>, "Neon1"
<neon1 at yahoo.com> wrote:

> Just started on the subject of enzyme inhibitors and already have been
> asked to draw a mechanism for cleavage of fructose 1,6 bisphosphate as
> catalyzed with the help of a lysine side chain in the enzyme aldolase. 
> I don't know where to begin since our textbook did not have examples of
> mechanisms of enzyme inhibitors.
> 
> Others:
> 
> 1) Draw the structures of the expected products of the yeast alcohol
> dehydrogenase (YADH) reaction with undeuterated acetaldehyde and NADH
> in D2O solution.
> 
> 2) Mechanism for the inactivation reaction of tosyl-L-phenylalanine
> chloromethyl ketone (TPCK) with chymotrypsin.  TCPK inhibits
> chymotrypsin by covalently labeling His57 >>> indicate structure of the
> product(s).  Based on the structure of TCPK what reagent might be an
> effective inhibitor of trypsin?
> 
> Can anyone help me out?  Thanks.
> --
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