Postdoctoral Position in Protein NMR

Honggao Yan yanh at pilot.msu.edu
Sat Dec 30 16:53:13 EST 2000


A postdoctoral position is available to study the structures and dynamics of
the enzymes in the shikimate and folate biosynthetic pathways. Since the
shikimate and folate biosynthetic pathways are unique to microbial and plant
worlds, the two pathways are ideal targets for development of antimicrobial
agents and herbicides. The long-term goals of the projects are to elucidate
the structure-function relationships of these proteins that account for
their catalytic mechanisms and to design specific inhibitors that may become
new antimicrobial agents. A variety of techniques is employed in these
projects, including recombinant DNA, biochemical, and biophysical methods.
The main structural technique is multidimensional NMR spectroscopy. These
projects are of great biomedical significance, especially in light of
rapidly increasing antibiotic resistance in recent years that has rendered
the current antibiotics ineffective for treating many microbial infections
and caused a worldwide health care crisis.

Our laboratory is well equipped for protein NMR spectroscopy.
Instrumentation includes three computer workstations (one from SGI and two
from Sun) and 500 MHz and 600 MHz Varian NMR spectrometers. The 600 MHz
Varian Inova NMR spectrometer is equipped with four rf channels and tri-axis
pulsed field gradients and is dedicated to biomolecular NMR studies. Funds
have been approved for acquiring a 900 MHz state-of-the-art NMR
spectrometer.

The initial appointment for the position will be two years and is renewable
upon mutual agreement. The applicants should have experience with
multidimensional NMR spectroscopy. If interested, please send a CV along
with telephone numbers and email addresses of three references to the
address below. Email responses are encouraged.

Dr. Honggao Yan
Department of Biochemistry
Michigan State University
East Lansing, MI 48824
Tel: (517) 353-8786
Fax: (517) 353-9334
Email: yanh at pilot.msu.edu



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