Psi amino acids?

Frank O. Fackelmayer Frank.Fackelmayer at uni-konstanz.de
Sat Feb 19 05:20:58 EST 2000


ChenHA wrote:

> On 16 Feb 2000, Mina wrote:
>
> > Recently, I found a consensus sequence described as : psi - K - X - E.
> > Can somebody tell me which amino acids belong to "psi", what
> > classification is that or just point me to a reference.
> >
>
> one possibility is that psi stands for pseudo - i.e. it means that the
> amino acids may be a pseudo-amino acid such as pseudo-proline or
> whatever residue that is unnatural or unusual.   For example, the CO
> or NH group may be replaced by CH2 group so that the peptide bond
> becomes non-hydrolysable, or the side-chains has other atoms or groups
> attached or replaced.

If it was phi instead of psi, I´d guess it stands for hydroPHobic. I´ve
seen this nomenclature someplace, but i´ve not been able to find it as a
standard (IUPAC) assignment. Hydrophobic amino acids are those with
aliphatic side chains, like e.g. leucine

Frank





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