post trans modification question

D.D. Morgan D.D.Morgan at ncl.ac.uk
Fri Mar 17 07:27:08 EST 2000


How does modification of a protein alter its apparent mwt on SDS-PAGE ?

Is it purely the increase in mwt due to the added residues or do they have
an effect on the overall charge of the protein altering its mobility ?

Any answers gratefully recieved and are there any basic references for a
"DNA man" to check out

Thanks

Dave Morgan

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