Serine strings

Pedro A Navarro pnavarro at uswest.net
Tue Oct 17 10:10:22 EST 2000


I am studying GP5 (envelope protein) from PRRS virus.  It was found by a
coleague that the presence of a Serine or Threonine residue can kill the
reactivity with a monoclonal antibody.  This new serine becomes part of
a serine string that "grows" from 3 or 4 serine residues in a row to 4
or 5 respectively (different strains have 3 some have 4).  My real
question is: is there any antigenic relevance on the presence of a
serine string.  This string is at the amino end and the substitution
takes place on aa34 (including signal peptide).

Sol M. Cancel
Graduate Student
Iowa State University






More information about the Proteins mailing list