Human protein digestion

Michael Witty mw132 at mole.bio.cam.ac.uk
Wed Jun 13 05:23:28 EST 2001


On Tue, 12 Jun 2001, laurie wrote:

>     I am seeking -detailed- information on the biochemistry of protein
> digestion in the living human.  Since biochemistry occurs strictly in
> 3-dimensional space, conventional vague, summarized accounts in
> zero-dimensional words are useless and misleading.
. . . but words can describe many many dimensions!

>     What is necessary is a 3-dimensional real-time, real-space,  analysis
> elucidating the 3-dimensional interactions between the
> structurally-identified enzymes and the structurally-identified substrates
> in the 4 stages of protein digestion, that -also- takes the 3-dimensional
> effects of cooking (denaturing) and subsequent partial renaturing of the
> protein structure into account, and specifically how the cooking process
> interferes with normal protein digestion.
>     Anyone know of a source?  Has this work been done?

I saw a great projection of a protein-in-motion in a seminar by Martin
Karplus on 30 April in Cambridge.  It was a model of protein dynamics
and was very good.  Contacting his group or similar may be a good start.

Regards, Mike.




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