proline rich

Artem Evdokimov AEVDOKIMOZ at
Tue Sep 25 19:15:28 EST 2001

Hard to say w/o sequence and hints to what this thing may do...

Could be structural - does the second protein have to work in harsh
environments, e.g. is it from a hyperthermophile ?


"Frits" <aristaless at> wrote in message
news:1001432012.424011 at
> Hi,
> What could it mean if two highly related proteins, clearly the product of
> duplicated gene, differ mainly in their proline content. One of the
> has a normal low protein content (about 3 %)  but among  a limited number
> differences in many cases the difference is that the second protein has a
> proline where the first does not, bringing the percentage on more than 12
> These mutations occur throughout the protein but the DNA-binding (homeo-)
> domain has been spared, wheress a second 'conserved' is not.
> --
> Frits

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