finding oligomers with "intertwined" structure

Frank Fürst ffrank at rz.uni-potsdam.de
Tue Aug 20 15:57:20 EST 2002


I am looking for examples of oligomeric proteins that don't consist of
associated independent structural domains, but rather form one domain
from the two (or more) polypeptide chains. I know of some examples: the
heterooligomers pea (2ltn) and lentil (1len, 1lal) lectin, which result
from proteolytical processing of one gene product, and some fibrous
phage proteins (e.g. see Mitraki et al, J. Struct. Biol. 137(2002),
236ff) or the C-terminal domain of homotrimeric P22 tailspike protein
(1tsp). But I'd like to have more of them.

Does anybody have an idea, or even a complete program or database link,
how I could search the protein structure database (pdb) for such
structures?

Thanks in advance, 
Frank
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