finding oligomers with "intertwined" structure
ffrank at rz.uni-potsdam.de
Wed Aug 21 03:02:57 EST 2002
"Artem Evdokimov" <AEVDOKIMOZ at cinci.rr.com> schrieb:
> Look into the cys-protease superfamily, especially the cathepsins, there are
> some interesting examples.
Do you mean http://www.biochem.ucl.ac.uk/bsm/cath_new/class3/90/70/10/
? I couldn't find information about the cleaved structures, at least not
in CATH or pdb. Do you have a link?
Chymotrypsin itself is an example, but there only one sheet is "mixed"
from both chains.
> IIRC, many proteases are expressed as single
> gene pre-proteins, then cleaved (often by themselves) into mature forms
> which are, technically, heterodimers.
Yes, sometimes there is some mixing of beta-strands. But the rest of each
chain is a quite independent building block with its own hydrophobic
core. In the structures I mentioned, the chains really make one domain
with a common hydrophobic core(s).
[Gesucht war ein MTA für Massenmailing]
Aus Stabilitätsgründen würde ich es allerdings vorziehen, wenn als
Server-OS nicht Debian-Linux sondern Windows-95 verwendet wird.
[Elmar Haneke in debian-user-de@]
More information about the Proteins