finding oligomers with "intertwined" structure

Artem Evdokimov AEVDOKIMOZ at cinci.rr.com
Wed Aug 21 20:54:32 EST 2002


> Do you mean http://www.biochem.ucl.ac.uk/bsm/cath_new/class3/90/70/10/
> ? I couldn't find information about the cleaved structures, at least not
> in CATH or pdb. Do you have a link?

More like

>
> Chymotrypsin itself is an example, but there only one sheet is "mixed"
> from both chains.
>
> > IIRC, many proteases are expressed as  single
> > gene pre-proteins, then cleaved (often by themselves) into mature forms
> > which are, technically, heterodimers.
>
> Yes, sometimes there is some mixing of beta-strands. But the rest of each
> chain is a quite independent building block with its own hydrophobic
> core. In the structures I mentioned, the chains really make one domain
> with a common hydrophobic core(s).
>
> Thanks, Frank
> --
> [Gesucht war ein MTA für Massenmailing]
> Aus Stabilitätsgründen würde ich es allerdings vorziehen, wenn als
> Server-OS nicht Debian-Linux sondern Windows-95 verwendet wird.
> [Elmar Haneke in debian-user-de@]





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