Bengt Erik Haug
bengt at chem.uit.no
Tue Jan 15 06:14:08 EST 2002
I´m having problems with workup after protecting a novel amino acid by
using Fmoc-OSu in water/DME with NaHCO3 as base. I get a byproduct with
"9-fluorenyl" signals on NMR, and the only way to get rid of it is by
flash-chromatography (time consuming...) Extracting the basic rx mix
with ether gives my protected aa in the ether phase with the byproduct.
Anyone had this problem, and worked out a better solution than mine?
Thank you for your help
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