How long is a protein sequence?

ChenHA hzhen at freeuk.com
Fri Dec 17 21:25:23 EST 2004



Dr Engelbert Buxbaum wrote:
> 
> Note that since proteins crystallised are often produced in bacteria by
> genetic engineering, and bacteria do not clip, 

Not true. 

Hirel et al, Proc Natl Acad Sci U S A. 1989 Nov;86(21):8247-51.
Extent of N-terminal methionine excision from Escherichia coli
proteins is governed by the side-chain length of the penultimate amino
acid.


> crystal structures
> (PDB-fiels) often contain the complete N-terminus. I have often wondered
> how this might affect the result...



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