[Protein-analysis] Re: Several questions

Tom Anderson via proteins%40net.bio.net (by twic At urchin.earth.li)
Tue Dec 12 18:16:53 EST 2006


On Tue, 12 Dec 2006, Fragemann wrote:

> 3. I was told that the more introns that you have, the greater your 
> lifespan. But if all genes are at fixed loci, how can one human have 
> more introns than another? It seems to me that loci positions would 
> restrict intron length.

Everyone has the same number of introns; every allele of a gene has the 
same pattern of introns and exons.

Well, more or less - there will be a few small mutations that interfere 
with splicing, and larger mutations that take out or duplicate entire 
genes or bits of genes, which will lead to variation, but not an awful 
lot.

Anyway, i know of no evidence for a correlation between number of introns 
and lifespan.

Unless, of course, you mean across species. Short-lived, fast-reproducing 
organisms tend to have fewer and smaller introns, since they slow down 
replication.

> 4. Lastly, in the current modern society, which person has more genetic 
> "fitness," the one who irresponsibly produces more children than they 
> can afford, or the one who has fewer because they spend their time 
> seeking a career, or because they are more responsible?

People who don't use usenet.

tom

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