[Protein-analysis] Re: Several questions

Fredo via proteins%40net.bio.net (by fredo At hotmail.com)
Wed Dec 13 16:56:32 EST 2006


> 3. I was told that the more introns that you have, the greater your
> lifespan. But if all genes are at fixed loci, how can one human have
> more introns than another? It seems to me that loci positions would
> restrict intron length.
>

Your other questions were answered.

I think you're confusing introns with telomeres here. There's not really a 
direct connection between telomere length and lifespan, but it works like 
this:

Telomeres are repetetive sequences at the end of chromosomes. When a 
chromosome is replicated, the ends get lost, so the telomeres act as a sort 
of buffer of losable material.

When you run out of telomeres, your DNA will start missing vital stuff, 
eventually, and then you'll die from a lack of one or more vital proteins. 
This is a problem with animal clones. The cloned DNA has whatever telomere 
length the parent had, whereas an ovum fertilized from a sperm gets its own 
brand new set of telomeres.

I don't think this is a normal cause of death in people. I think organs 
usually give out, or disease develops, before your run out of telomeres, but 
I could be wrong. 




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