A postdoctoral position (BAT II a) is available in a laboratory working
on Molecular Parasitology and Signal Transduction
http://www.uni-duesseldorf.de/WWW/MathNat/Parasitology/
The group in Duesseldorf is working on signal transduction molecules in
the human parasitic worm Schistosoma mansoni. These molecules
govern the maturation program of vitelline cells in females, an
essential developmental process that is induced by pairing with the male. After
identification of a couple of female-specifically expressed genes whose
activity is regulated by the male, the new project concerns techniques
that have been successfully used in signal transduction research during
the last few years. The program tries to identify further signalling
molecules that react with known molecules by protein-protein
interaction.The methods include the yeast two-hybrid system, cloning of
receptor
targets and others. The final goal is to elucidate the signalling
pathway that regulates vitelline cell proliferation and differentiation in
female schistosomes and to open ways to inhibit their action.
Literature:
Grevelding, C.G., Sommer, G., and Kunz, W. (1997). Female-specific gene
expression in Schistosoma mansoni is regulated by pairing. Parasitology
115, 635-640.
Schuessler, P., Grevelding, C.G., and Kunz, W. (1997). Identification of
Ras, MAP kinases, and a GAP protein in Schistosoma mansoni by
immunoblotting and their putative involvement in male-female interaction.
Parasitology
115, 629-634.
Information:
Prof. Dr. Werner Kunz
Section of Genetic Parasitology
Institute for Genetics, Heinrich-Heine-University, Universitaetsstr.1,
D-40225 Duesseldorf, Germany
Tel.+ Fax: (49)211-81-12333
E-mail: Werner.Kunz at uni-duesseldorf.de
