microarrays

David Johnston daj at nhm.ac.uk
Thu Jun 18 01:34:17 EST 1998


 Dear Colleagues,
 
 at the 1998 meeting of the WHO Schistosoma Genome Network, it was decided
 to apply for funds to generate high density arrays of the known schistosoma
 gene set that has been generated by EST analysis. By the end of the year we
 estimate that there will be some 4000 unique sequences available, from
 adult (mixed and separate male and female), cercarial, egg, lung and
 miracidial cDNA libraries for S mansoni and S. japonicum). Depending on the
 relative costs involved (still being investigated), the gene sets would be
 prepared as either microarrays on glass slides or as high density grids on
 nylon filters. These would then be available for the community to use to
 assay changes in gene expression, for example;
 
 between different life cycle stages
 between male and female worms
 between immature, sexually mature and reproductively senescent female worms
 between drug resistant and susceptible parasites
 on temperature shock
 etc. etc.
 
 If you would be interested in using these arrays, I would be very grateful
 to receive from you, an email or (preferably) a fax on headed paper,
 supporting the production of this resource, that can be included in the
 appliication.
 
 Thanks in advance,
 
 David.
 
 David A. Johnston,
 Secretary to the WHO Schistosoma Genome Network,
 Biomedical Parasitology Division,
 Dept. of Zoology,
 The Natural History Museum,
 Cromwell Road, London SW7 5BD, England, UK.
 Tel: 0171-938-9297 (from outside the UK: 44-171-938-9297)
 Fax: 0171-938-9297 / 9249 / 8754 (from outside the UK: 44-171-938****)
 eMail daj at nhm.ac.uk
 
 Please note the new WW site address:
 http://www.nhm.ac.uk/hosted_sites/schisto/
 
 The  Biomedical Parasitology Division is a WHO Collaborating Centre for the
 identification of schistosomes and their snail hosts.
 
 




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