Humboldt-Universität zu Berlin
Lehrstuhl für Molekulare Parasitologie
AG Schistosomen
PhD position (Salary: BAT IIa/2, German Research Council)
to work in the following project areas:
- Studies on the function of Cathepsin D of Schistosoma mansoni utilising
transgenic worms.
The role of Cathepsin D will be studied with reverse genetics (transgenic
worms, knock-outs, inducible expression) and biochemical methods
(fluorometrie). Aim of the study is also to validate Cathepsin D as a
therapeutic target.
- Isolation und characterisation of the promotor of the schistosomal
aspartic protease
To express the transgen in Schistosomes it is important to characterise
promotor- and regulatory sequences of the aspartic protease gen. In this
project a genomic DNA library of S. mansoni will be screened with specific
probes, clones sequenced and positive clones characterised further.
- Protective potential of the aspartic protease of Schistosoma mansoni
Recombinant protein (insect cell system) and DNA-vaccine vectors will be
used to immunise laboratory animals. The humoral and cellular immune
responses will be characterised.
Prerequisites: Strong base in Molecular Biology, Biochemistry, Parasitology
or Immunology.
Information and applications:
Humboldt-Universität zu Berlin, Lehrstuhl für Molekulare Parasitologie,
AG Schistosomen, Philippstr.13, 10115 Berlin
Dr. Bernd Kalinna
Tel: 030-2093-6055
Fax: 030-2093-6051
email: bernd.kalinna at rz.hu-berlin.dehttp://www.biologie.hu-berlin.de/molpara/web/index.html
