PhD position (English version)

Bernd Kalinna bernd.kalinna at rz.hu-berlin.de
Mon Aug 2 06:48:15 EST 1999

Humboldt-Universität zu Berlin
Lehrstuhl für Molekulare Parasitologie
AG Schistosomen

PhD position (Salary: BAT IIa/2, German Research Council)

to work in the following project areas:

- Studies on the function of Cathepsin D of Schistosoma mansoni utilising
transgenic worms.

The role of Cathepsin D will be studied with reverse genetics (transgenic
worms, knock-outs, inducible expression) and biochemical methods
(fluorometrie). Aim of the study is also to validate Cathepsin D as a
therapeutic target.

- Isolation und characterisation of the promotor of the schistosomal
aspartic protease

To express the transgen in Schistosomes it is important to characterise
promotor- and regulatory sequences of the aspartic protease gen. In this
project a genomic DNA library of S. mansoni will be screened with specific
probes, clones sequenced and  positive clones characterised further.

- Protective potential of the aspartic protease of Schistosoma mansoni

Recombinant protein (insect cell system) and DNA-vaccine vectors will be
used to    immunise laboratory animals. The humoral and cellular immune
responses will be characterised.

Prerequisites: Strong base in Molecular Biology, Biochemistry, Parasitology
or Immunology.

Information and applications:

Humboldt-Universität zu Berlin, Lehrstuhl für Molekulare Parasitologie,
AG Schistosomen, Philippstr.13, 10115 Berlin

Dr. Bernd Kalinna
Tel: 	030-2093-6055
Fax:	030-2093-6051
email: bernd.kalinna at rz.hu-berlin.de


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