ricin toxicity

Chuck Miller rellim at MAILHOST.TCS.TULANE.EDU
Thu Oct 12 08:56:51 EST 1995


Hi Scary Gary and other Bionet.toxicology fans,

I am a little puzzled by the meaning of "albumin actions" in your subject
header.

Ricin does have agglutination properties, but this is not related to toxicity.

Ricin is a lectin that comes from the seed (bean) of Ricinus communis.
Ricin is composed of two protein chains. One protein facilitates entry of
the toxin across the cell membrane. Once inside the cell the toxic protein
component binds to ribosomes and inhibits protein synthesis, causing cell
death. The Merck Index states that ricin is one of the most toxic
substances known, producing lethality (by i.p. injection) at doses of 1 ng
ricin nitrogen/g body weight in mice. 

Virtually yours,

Chuck



Dr. Charles A. Miller,  rellim at mailhost.tcs.tulane.edu 
Bionet.Toxicology News Group Discussion Leader
Dept. Environmental Health Sciences 
Rm. 374, Center for Bioenvironmental Research
School of Public Health and Tropical Medicine
Tulane University Medical Center  
1430 Tulane Ave. Box SL29                 
New Orleans, LA 70112               
Ph. 504-585-6942, Fx. 504-585-6939              

                                                                        
                   






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