Animal models

John Budny jabudny at earthlink.net
Tue Apr 23 23:27:48 EST 1996


GWOLFF at NCTR.FDA.GOV ("George L. Wolff") wrote:
>I agree with Chuck Miller's post re "resemblance" rather than 
>"identity" of animal models and their supposed human counterparts.  
>My question always is "Which human" when supposed relevance of an 
>animal model to humans in general is mentioned. 
>

Makes sense.  Sounds like George and Chuck have had experience in the 
real world of toxicology.  "Wouldn't it be nice if all models were 
identical"  Get a life Jack!  It does not work that way.  Budny's First 
Law of Biology: "Mother Nature has a mind of her own."

I agree with both of you.  Now what I believe we have settled or at least 
until someone violently disagrees with the three of us, time-course of 
the disease (toxicant-induced because Paul may disagree that toxicant 
and vector diseases may be different)is a consideration that should be 
taken seriously without the burdensome requirement that the time-course 
be identical.  Is that agreeable to one and all?

Jack Budny
jabudny at earthlink.net





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