Animal Models

John Budny jabudny at earthlink.net
Tue Apr 23 23:18:02 EST 1996


p.whitehead at dial.pipex.com (Paul Whitehead) wrote:
>jabudny at EARTHLINK.NET ("John A. Budny") wrote:
>
>>Should a criteria for an animal model for toxicology be that the time-course
>>and characteristics of the toxicologically-induced
>>disease state resemble, replicate or be identical to the toxicant-induced
>>disease condition in humans?
>
>Clearly we have to distinguish between toxicant  induced disease and
>vector induced disease.   Many diseases are species specific, cf your
>comment re tuberculosis, and pharmacologists have different models,
>often isolated tissues, to study efficacy and pharmacodynamics.
>
>
>
>Paul Whitehead BSc CBiol MIBiol DABT
>United Kingdom
>e-mail p.whitehead at dial.pipex.com
>

Paul,

See George Wolf's comments that would seem to imply the opposite i.e. the 
distinction between vector mediated disease and toxicant mediated 
disease, according to George are the same - maybe I shouldn't speak for 
George.

John A. Budny
jabudny at earthlink.net




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