Animal Models

John Budny jabudny at
Tue Apr 23 23:18:02 EST 1996

p.whitehead at (Paul Whitehead) wrote:
>jabudny at EARTHLINK.NET ("John A. Budny") wrote:
>>Should a criteria for an animal model for toxicology be that the time-course
>>and characteristics of the toxicologically-induced
>>disease state resemble, replicate or be identical to the toxicant-induced
>>disease condition in humans?
>Clearly we have to distinguish between toxicant  induced disease and
>vector induced disease.   Many diseases are species specific, cf your
>comment re tuberculosis, and pharmacologists have different models,
>often isolated tissues, to study efficacy and pharmacodynamics.
>Paul Whitehead BSc CBiol MIBiol DABT
>United Kingdom
>e-mail p.whitehead at


See George Wolf's comments that would seem to imply the opposite i.e. the 
distinction between vector mediated disease and toxicant mediated 
disease, according to George are the same - maybe I shouldn't speak for 

John A. Budny
jabudny at

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