Animal Models in Toxicology
ramjoshi at duke.usask.ca
Mon Feb 12 17:27:22 EST 1996
On 12 Feb 1996, DrJackBud wrote:
> Someone, anyone - help Whitehead and myself. There must be a better
> reason for doing toxicological investigations and research other than for
> "regulatory authority demands". Otherwise, why try to develop models?
> Some of you toxicologists surely must have some thoughts that would help
> Whithead and myself???
Well... animal models (e.g., in vitro studies) can help determine whether
certain drugs are worthwhile pursuing as a course of treatment in various
pathological conditions (e.g., cellular damage) brought about when the
system is challenged by toxins (e.g., pesticides). If data from the
model shows good supporting evidence for the effectiveness of the drug
against the toxin, then the drug can go to the next stage for testing
and evaluation. Animal models are useful as they usually give good
preliminary indications whether a drug has the potential for its ultimate
use in humans.
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