Animal Models in Toxicology

[Paul Whitehead]

p.whitehead at dial.pipex.com (Paul Whitehead) wrote:

 
 
>Off the top of my head I cannot recall an example of a unique human
>toxicant that cannot in some way be shown to be toxic under some
>conditions in animals.  The most likely  scenario is that the toxicity
>is missed at the first pass due either to the inadequacy of the animal
>model or the narrow requirements of regulatory authorities, eg
>thalidomide teratology in rabbits, benoxyprofen toxicity in geriatrics
>due to pharmacokinetic differences, etc.

Actually, I have just thought of one - the Spanish toxic oil syndrome.

 

Paul Whitehead BSc CBiol MIBiol DABT
United Kingdom
e-mail p.whitehead at dial.pipex.com