Animal Models in Toxicology
p.whitehead at dial.pipex.com
Tue Feb 13 12:14:00 EST 1996
p.whitehead at dial.pipex.com (Paul Whitehead) wrote:
>Off the top of my head I cannot recall an example of a unique human
>toxicant that cannot in some way be shown to be toxic under some
>conditions in animals. The most likely scenario is that the toxicity
>is missed at the first pass due either to the inadequacy of the animal
>model or the narrow requirements of regulatory authorities, eg
>thalidomide teratology in rabbits, benoxyprofen toxicity in geriatrics
>due to pharmacokinetic differences, etc.
Actually, I have just thought of one - the Spanish toxic oil syndrome.
Paul Whitehead BSc CBiol MIBiol DABT
e-mail p.whitehead at dial.pipex.com
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