Animal Models in Toxicology

DrJackBud drjackbud at aol.com
Thu Feb 15 06:53:50 EST 1996


In a post by Ronald Young on 14Feb96 [Subject: Cadmium] he states: "The
following may be of interest to the discusion of animal models and their
relevance to humans.  Cadmium is a potent testicular poison in animals
resulting in infertility.  Long occupational association with this metal
does not appear to compromise the fertility of exposed human males."

Has EPA (Water Quality Standards), FDA (food tolerances), OSHA
(occupational exposure standard) or other non-US regulatory agencies used
the animal testicular no effect level, or some safety factor thereof, to
establish standards?  Does anybody know?



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