Chloramphenicol resistance

Mark Fuller mark_fuller at qmgate.anl.gov
Wed Jul 17 10:49:00 EST 1996


Does anyone have a few references to the mechanism by which 
chloramphenicol (and other nitroaromatic antibiotics) are rendered 
ineffective.  I've heard of low membrane permeability, active transport 
of Chl out of the cell and acetylation, but I don't have any of the 
references for these.  Also, are gram-positive organisms likely to be 
more sensitive to chloramphenicol/nitroaromatic compounds?

Any help would be much appreciated.

Mark Fuller, Ph. D.
Environmental Research Division € ER/203-J070
Argonne National Laboratory
Argonne, IL  60439-4843
 
phone: (708) 252-1795
FAX: (708) 252-8895
email: mark_fuller at qmgate.anl.gov





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