metal genotoxicity

Michel Assad assad at ANUBIS.JUSTINE.UMONTREAL.CA
Wed Jul 17 16:04:38 EST 1996


Two hypotheses seems to emerge to explain metal carcinogenicity: 
induction of oxidative damage and interaction with DNA repair. However, 
can metals cause promutagenic damage such as DNA strand breaks !!! I 
am looking for any relevant reference underlying the mechanism.

Thanks for any help or reference.


Michel Assad
Canada
E-mail: assad at justine.umontreal.ca 
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*	Michel Assad
*	 Paediatric Research Center
*	  Ste-Justine Hospital
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*	     CANADA
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