NEWSFLASH:- Momentum gathers for ban on Dental Amalgam.

pcsol at tcp.co.uk pcsol at tcp.co.uk
Thu Feb 27 11:48:33 EST 1997


NEWSFLASH:- Momentum gathers for ban on Dental Amalgam.

The first two reports below were taken from latest issue of 
BIOPROBE magazine, and the last report, the new research evidence 
on the Alzheimers/Amalgam link, from BIOPROBE and 
other news sources. They cover dramatic new research and news 
developments in the USA, Canada and Germany, casting the 
strongest doubts on the safety of Dental Amalgam.
For more info from Bioprobe publications see 
http://www.bioprobe.com
Also see list of links given at end of text..

cheers
ade

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AMALGAM "COVER UP" EXPOSED IN CANADA!!

"Decouverte" is the French word for "Discovery."  It is the title 
of a respected news program on the French network of the 
Canadian Broadcasting Corporation.  Decouverte's mission is to 
"discover" scientific issues that might be covered up.  Last 
October, Decouverte aired a 16 minute report on the health risks 
of amalgam following publication of Health Canada's Position 
Paper on the issue.  The show was so unfavorable to the 
pro-amalgam position that it elicited public outcry in dental 
offices everywhere in Quebec.  The following week, the Order of 
Dentists of Quebec published rebuttals in major newspapers 
across the province to reassure dental patients of the "total safety 
and biocompatibility" of dental amalgam!
On 23 February, Decouverte aired a second report on amalgam, 
this time exposing Health Canada's failure to inform Canadians of 
the possible dangers of this material.  Since 1976, four Health 
Canada reports by medical scientists have warned of these 
dangers; only in 1996 did Health Canada publish a position 
statement on amalgam, recommending dentists limit its use in 
certain groups of patients.
The program started with host Charles Tisseyre informing 
viewers that a group of Canadian dental patients had this week 
announced their intention to file a class action suit against Health 
Canada, the Canadian Dental Association and amalgam 
manufacturers for failure to inform them of the possible side 
effects of amalgams.
Since 1982, according to Canadian law, all medical devices 
destined to be implanted in the human body for more than 30 
days must have pre-market studies done to prove their safety and 
biocompatibility.  The president of the Canadian Dental 
Association admitted his predecessors and the dental industry had 
lobbied the government to exclude dental restorative materials 
"that do not come into contact with blood" from this law.  
Decouverte obtained information that this was to protect small 
amalgam manufacturers who did not have the necessary funds to 
complete these studies.
Dr. Pierre Blais, former risk analyst with Health Canada and 
author of its 1976 report on amalgam, denounced this lack of 
quality control saying how "he could manufacture cadmium or 
other metal filings and sell them as amalgam and it would take 
months or years before it would be found out."  He shared how 
the continued use of amalgam was contrary to Health Canada's 
policy on mercury hygiene and pollution control: "The 
Government was concerned over picograms and micrograms of 
mercury in apples and looked the other way when milligrams, 
one million times more, were being implanted directly into a 
child's mouth."
When asked why it took 20 years to publish a position paper on 
amalgam, Richard Tobin, Director of Health Canada's Medical 
Devices Bureau, said in interview that he was not aware that 
Canadians were not informed of the possible dangers of amalgam 
and that the risk was deemed minimal anyway.  Questioned about 
the Quebec Order of Dentists advertisement claiming "total 
safety" of amalgam mercury exposure, Dr. Tobin said he was not 
in agreement with it and he would have to discuss it with the 
Order.  The president of the Quebec Order of Dentists declined 
invitation to be interviewed and explain his point of view on 
Decouverte.
Dr. Mark Richardson's studies on the relative risks of mercury in 
amalgams and bisphenol-A in composites were quoted: The 
average Canadian, with 8 amalgams, was 3.5 times over the daily 
threshold limit for mercury exposure, whereas the patient with 8 
composites was 125 times UNDER the daily threshold limit 
value for escaping bisphenols-A.
The program concluded with both CDA President, Dr. Barry 
Dolman, and Dr. Pierre Blais agreeing, in the end, that the dental 
patient must beware and take responsibility for his/her own 
health.  Health Canada is presently revamping its medical devices 
policies; there are currently no plans to require pre-market studies 
for amalgam.
Comment: Richard Tobin of Health Canada was courageous to 
answer questions from reporter Michel Rochon, but he just did 
not have the answers!  The fact that the Order of Dentists, 
Quebec's licensing body and government appointed public 
protector, would not appear on the program was very detrimental 
to them.  Health Canada's disagreement with their advertisement 
on the "total safety" of amalgam mercury exposure and their 
refusal to appear on the show further damaged their rapidly 
diminishing credibility on the dental amalgam controversy.  
Signed Pierre Larose

BIO-PROBE COMMENT: We are grateful to Dr. Pierre 
Larose for providing this timely report on the Decouverte 
program.  The key factor in this important expose' is the fact that 
four internal studies by Health Canada scientists were buried.  
The Medical Devices Act of Canada mandates Health Canada 
with the "duty to inform", a duty which was clearly and 
shamefully ignored.  Dr. Pierre Blais, in a memorandum to the 
Chief of the Division of Medicine for Health Canada on his 1976 
study questioning the safety of amalgam mercury, stated: "The 
potential hazards associated with the [amalgam] products are so 
transparently obvious that we cannot even appear to ignore it 
without attracting ridicule."
The fact that Health Canada failed to inform the Canadian 
citizens of these four studies for twenty years demands 
accountability from the responsible officials. The 
recommendations of these studies should not have been ignored,  
in favor of yielding to the influence of the dental establishment, 
for whatever reason.  The first responsibility of the Health 
Canada officials is supposed to be to the citizens, not to a special 
interest group.  The following article adds further insight to the 
rapidly developing situation in Canada.

AMALGAM CLASS ACTION SUIT IN CANADA

On 17 February 1997, two organizations provided press releases 
announcing a possible class action suit against dental amalgam in 
Canada.  These organizations are "Canadians for Mercury Relief 
(CFMR)" in Toronto and "Alliance For Public Accountability 
(AFPA)" in Ottawa.
The CFMR release opened with: "The silver dental fillings that 
you have been receiving are comprised of fifty percent mercury 
and have been exposing you to mercury vapor concentrations in 
your mouth, that in many cases exceeds the World Health 
Organization's Safe Occupational Exposure Limits by as much as 
1200%."  The release went on to cite the twenty year old study of 
Dr. Pierre Blais for Health Canada.  A spokesperson for CFMR 
emphasized that the purpose of the lawsuit was to educate 
Canadians and dentists alike as to their options and also the 
importance of proper procedures for the removal of mercury 
amalgam fillings.
CFMR has retained the Toronto law firm of Paroian, Raphael, 
Courey, Cohen & Houston to take preliminary steps prior to the 
commencement of a class action lawsuit.  The primary thrust of 
the potential legal action is based on the fact that Health Canada 
failed in its duty to inform the citizens of Canada of the results of 
its own internal studies questioning the safety of mercury 
exposure from dental amalgam fillings.
The AFPA news release expressed full support for the CFMR 
action and stated: "We believe that it is imperative that their 
message be heard, as it affects so many Canadians.  Citizens have 
a right to know the potential risks they are taking in using 
Mercury Amalgam."  The two groups held a joint news 
conference at the law firm at 10:00 am on Thursday, 20 February 
1997.

AMALGAM BAN DEMANDED IN GERMANY

The following Press Release From Germany has been translated 
by Mats Hanson, Ph.D. of Sweden. 
BUND, Friends of the earth.  The Association of Environment 
and Environmental Protection, Germany.  Dunanstrasse 16, 
D-79110 Freiburg
Freiburg/Bonn, 28 January 1997
Review/Background Information
Presentation of the results of the largest trial on mercury release 
from dental amalgam fillings in world,
BUND demands:  <R>No respite for amalgam - Amalgam 
ban overdue.
Amalgam has been the dental filling material of choice since 150 
years.  The criticism of this debated material has now been 
further strengthened after the current results of the Tbingen 
amalgam tests.
The largest test In the world on mercury release from amalgam 
fillings into the saliva was initiated in summer 1995 by BUND 
and carried out by the department of environmental analysis at the 
university of Tbingen.  After a few hundred tests at the BUND- 
Environmental exhibition ™KO-95 in Ulm had shown a mean of 
more than four times higher mercury levels in the saliva than the 
Bundesgesundheitsamt had reported, BUND decided to act 
because of apparent governmental inactivity.  Funded by the 
MOMO-Children Foundation, we engaged the environmental 
analytical group at the university of Tbingen for the scientific 
realization of the largest experiment in the world on mercury 
release from dental amalgam fillings.  The analysis of the data 
have been completed and sent to the Bundesinstitut fr 
Arzneimittel und Medizinprodukte for publication.
Part 1: Mercury concentration In saliva from amalgam 
fillings.
In the first part of the study mercury levels in the saliva were 
measured in 20,000 persons and related to the number of 
amalgam fillings.  The aim was to evaluate whether and to what 
degree there was an exposure to mercury from amalgam fillings. 
 The second part of the study examined the relation between the 
levels of mercury In saliva and a special spectrum of symptoms.
Mercury levels strongly elevated.
The more than 4-5 times higher mercury levels in saliva 
compared to the levels reported by the former 
Bundesgesundheitsamt in 1984 (now Bundesinstitut fr 
Arzneimittels und Medizinalprodukte) caused alarm, both among 
the public as well as among professionals.  The continuation of 
the analyses were increasingly made more and more difficult for 
the scientists at the University of Tbingen, a sign of the alarming 
nature of the results.  In addition to a great deal of irrelevant 
criticism, it was also reported that WHO had distanced itself from 
interpretations of the Tbingen study, which also proved to be 
false.  Especially the exceeding of the established tolerable limits 
caused worry: The total tolerable weekly uptake of mercury 
(including the vapor phase) of WHO was exceeded.  About 43 % 
of the test persons had higher, often several fold, exposure than 
the permissible intake.  Since it has already been demonstrated 
that the mercury in the saliva is dissolved but  not particulate, one 
has to calculate with a much higher absorption and mercury load 
than previously supposed.  Of importance is that in the 20-39 
year old group (including women in the fertile ages) the tolerable 
levels were especially often exceeded.  This can be explained by 
the fact that the number of fillings in this group is especially high 
with 9-11 fillings, compared to a mean of 8 in the general 
German population.  The tolerable intake was also often 
exceeded for children with fewer fillings because of their lower 
body weight.
Mercury load from amalgam fillings.
As a further statistical result the study established that the 
mercury concentration in saliva (before and after chewing) 
depends on the number amalgam fillings.  The exposure lo 
mercury from amalgam fillings has been scientifically debated, 
The results from the Tbingen study clearly show an increased 
mercury load from amalgam fillings.
Saliva test a method to establish the mercury load.
The criticism of the Tbingen amalgam study concentrated on the 
question whether saliva was a better medium than for instance 
blood and urine to evaluate mercury exposure, Recent research 
confirms the advantages of the saliva test.  The load on the oral 
cavity and the gastrointestinal tract can be estimated better with 
the saliva test than with any other available method.  Hg can be 
present in both the oral cavity and the gastrointestinal tract 
without being detectable In blood or urine.  It is clear that blood 
and urine do not reflect the Hg-concentration in the oral 
cavity/upper airways and in the gastrointestinal tract.  In addition, 
it was not possible to obtain a certification/standardization for 
either blood (Dtsch Ges fr Arbeitsmed) or urine (Dtsch Ges fr 
Kiln Chem) in the exposure range relevant for amalgam fillings.  
In contrast, a standardization test by the State Medical Dept of 
Stuttgart confirmed the excellent reproducibility for the saliva 
test; laboratories which processed the samples with the same 
method obtained consistent results; the standard error between the 
10 laboratories was less than 15 %.
Part 2. Measured levels In saliva and disease symptoms.
Every saliva test was accompanied by a questionnaire In which 
the persons were asked for 30 symptoms.  The analytical group at 
Tbingen university evaluated 17500 completely answered 
questionnaires.  The question was whether there was a significant 
relation between report of a symptom and the measured level of 
Hg in the saliva after chewing.
It has to be stressed that the established relation has a direct 
mathematical and statistical character and should not be casually 
interpreted. A statistically significant difference does not 
automatically mean a medical or biological relevance.  Not even 
multi variance analysis can decide which relations are caused by 
chance and which by a casual relation.
Relation between symptoms and mercury concentrations in 
saliva after chewing.
The Tbingen amalgam study could establish in the especially 
examined group of 21-40 year old persons a statistically 
significant relation between mercury levels in saliva and 
symptoms.  Only symptoms which are characteristic of subacute 
or chronic mercury exposure in the low-level range were studied.
The set of symptoms are often called micromercurialism in 
the literature,
There was a significant relation between the measured mercury 
concentration and the following symptoms:
1. Mouth-oral cavity: Bleeding gingiva, metal taste, burning 
tongue.
2. Central nervous system: Concentration difficulties, impaired 
memory, sleep disturbances, lack of initiative, nervousness.
3. Gastrointestinal tract: not specified; further research is needed 
to establish the diseases which are covered by the non- specific 
label gastrointestinal problems.
Plausibility and explainability of the demonstrated 
symptoms.
In addition to high levels of mercury in saliva there has also been 
demonstrated high levels In gingiva, pulp, oral mucosa, dentine, 
roots and jaw bone.  Amalgam fillings, as described in the 
literature, lead to increased inflammation of the gingiva. In 
addition the oral cavity will be affected by the Hg-vapor released 
by the fillings.  Experiments with cell cultures demonstrated that 
the Hg-levels measured in the oral tissues (up to 8000 ng/g in the 
mucosa) can lead to damage to human cells.  It has also been 
described that unpolished amalgam fillings can damage nearby 
cells more than polished ones.
Also for the gastrointestinal tract it has been demonstrated that 
there are high levels of mercury in the intestinal wall, intestinal 
lymph nodes and in feces.  The cause of this is that the mercury 
which is swallowed with the saliva is only absorbed to 10% and 
the rest remains in the gastrointestinal tract.
For both these body parts it has been established that blood and 
urine levels are unsuitable to evaluate the mercury load.  The 
symptoms from the central nervous system show a remarkable 
similarity with the classical mercury symptoms described in the 
literature.  For instance, effects of mercury on memory and 
concentration has been repeatedly described in the literature.
The Tbingen group for environmental analysis stress that some 
aspects of the study require further examination.  For instance, 
the relationships between mercury exposure to metal allergy, or 
loss of hair,  or the relationship to involuntary infertility.  In
each 
of these considerations, tendencies were noted, however, 
extensive and expensive further questionnaires are required.  It 
should be stressed that the results are statistical and do not 
establish a causal relation for single cases for any symptom.
After the statistical relations found in the study, persons who 
complain over problems with amalgam must not further be 
dismissed a "Ecochondriacs" or Hypochondriacs," and 
furthermore a possible Hg-load must be take into account in the 
anamnesis, especially when the patients exhibit the described 
symptomatology.
Amalgam is with certainty not the material for the future, the 
Tbingen group stress, however they also warn for exaggerated 
panic reactions.  As in medicine In general, In every single case 
one must together with the treating doctor evaluate whether an 
amalgam removal is necessary and if yes, how rapidly a removal 
should take place.
The relations found, which as stated above, should not be 
causally interpreted, however clearly prove that humans will be 
exposed to a continuous load of mercury from amalgam fillings.  
The filling material amalgam is thus suspected of being able to 
cause damage to health,
This should be sufficient for health policy measures and at last 
start to end the amalgam era.
Demands by BUND as a consequence of the amalgam study:
- BUND demands that minister of health, Seehofer, immediately 
acts on the basis that: Amalgam, as an additional risk factor, does 
not belong in the oral cavity.
- The amalgam ban should not only be restricted to pregnant 
women and children but should immediately be general for 
dentistry.
- The university dental clinics must immediately remove the 
technique of amalgam placement from their educational agenda, 
as has already happened in renowned dental clinics in 
Switzerland.
- Teaching and education on amalgam problems, safer removal 
techniques for amalgam filling and on plastic alternatives for 
molar teeth.
- Further studies are indicated by the amalgam study.  The 
Minister of Health Seehofer must not further burden 
environmental organizations with the expenses,
- BUND demands that the Minister of Health release funds for 
follow-up studies at the Uuniversity of Tbingen.
- After an overdue amalgam ban the costs for alternative materials 
must be taken over by the insurance s stem
Dental metal test can be mediated by all pharmacies. BUND can, 
in cooperation with the environmental analytical group at 
Tbingen, offer under the name SALIVAGAM a dental metal 
test.  This can be mediated by all pharmacies.  In addition to 
mercury levels in saliva all other dental metal are analyzed.  
Further information in all pharmacies and from 
BUND-Umweltlabor, Tel: 0781/9383-21, Fox-11
For answers to scientific matters please contact Dr E Roller, Dr. 
HD Wolss, KH Maier, AK Umweltanalytik, Univ. of Tbingen, 
Postfach 210352, D-72026 Tbingen, tel 07071/2984802.  
Interested journalists can  obtain detailed  information  from 
BUND, Dunanstrasse 16. D-79110 Freiburg, Tel: 
0761/885955-0, Fax-90

ALARMING NEW RESEARCH EVIDENCE FROM THE 
USA.

This is dated Dec 1996 - quite recent. Dr Haleys is a biochemist 
of world repute - his work is already well known. He is a 
member of the University of Kentucky's huge multi-million dollar 
long-term research project examining the causes a Alzheimers 
Disease - there are probably very few more eminent or 
knowledgable in this field. Dr Murray Vimy is also a researcher 
of repute, and a former World Health Organisation consultant. 
The journal from which the full extract is quoted (FASEB) is a 
highly regarded and main-stream scientific medical publication.

The following quote is from The Valley Advocate, December 5, 
1996.

"A team of scientists led by Dr. Boyd Haley recently completed a 
study exposing six laboratory rats to a typical intake of amalgam 
mercury vapor, diluted to account for the size difference between 
rats and humans. To the researchers' astonsihment, every rat 
developed symptoms and brain tissue damage indistinguishable 
from that of Alzheimer's Disease patients. The reseachers then 
repeated their experiment only to find the same results. While the 
jury is still out for human patients, the leader of the research team 
had seen enough. Dr.Bronte's new book The Mercury in Your 
Mouth: The Truth About 'Silver' Dental Fillings quotes Dr. 
Haley's response to the group's findings. 'The results of this 
experiment are terrifying,' he said. 'I'm getting the rest of my 
fillings taken out right now, and I've asked my wife to have hers 
replaced too.'"

Thanks to Dagfinn Reiersol for supplying this newspaper quote.. 
See his page: http://home.sol.no/reiersol/amalgam.htm

TITLE: Mercury Vapor Exposure Inhibits Tubulin Binding to 
GTP In Rat Brain: A Molecular Lesion Also Present in Human 
Alzheimer Brain.
AUTHORS: Lorscheider, FL; Vimy, MJ; Pendergrass, JC; 
Haley, BE.
SOURCE: FASEB J. 9(4): A-3845. FASEB Annual Meeting, 
Atlanta, Georgia, 10th March 1995.

ABSTRACT: Methyl mercury will interact with tubulin causing 
disassembly of microtubules that function to maintain neurite 
structure. Numerous reports also establish that mercury vapor 
(Hgo) is continuously released from "silver" amalgam tooth 
fillings into mouth air. In the present study rats were exposed to 
Hgo 4 h/day for 0, 2, 7, 14 and 28 days at 250 mcg Hg/m 3 air, a 
concentration present in mouth air of some humans with large 
numbers of amalgam fillings. Average rat brain Hg 
concentrations increased significantly (40-100 fold) with duration 
of Hgo exposure. By day 14 of Hgo exposure, photoaffinity 
labelling of the b-subunit of the tubulin dimer with [a32 
P]8N3GTP in brain homogenates was decreased 75%, as seen on 
analysis of SDS-PAGE autoradiograms.
The identical neurochemical lesion of similar magnitude is 
evident in Alzheimer brain homogenates when compared to 
human age-matched controls. Since the rate of tubulin 
polymerization is dependent upon binding of tubulin dimers to 
GTP, we conclude that chronic inhalation of low-level Hgo can 
inhibit polymerization of tubulin essential for formation of 
microtubules.

BIO-PROBE COMMENT: This study represents the latest 
information possibly connecting mercury to Alzheimer's Disease 
(AD). The information began some ten years ago with human 
autopsy studies conducted at the University of Kentucky. Three 
published studies showed high levels of mercury in AD brains 
compared to controls; first in whole brain tissue, then regional 
levels where AD damage is predominant, and finally in cellular 
and subcellular fractions. Next, other scientists the University of 
Kentucky found AD-type damage in rats fed mercury, while no 
damage was found in the aluminum-fed rats. The next step was 
the discovery of the AD-type molecular lesion found in rats that 
were fed  mercuric chloride in drinking water. This latest study 
found the AD-type molecular lesion in rats that were 
administered mercury vapor in the amounts to which some 
humans with large numbers of amalgam fillings are exposed.

-----------------------------------------------------------------------
http://ourworld.compuserve.com/homepages/pcsol  (UK Amalgam page)
http://www.vimy-dentistry.com/	                (Dr Vimys page)
http://www.algonet.se/~leif/AmFAQigr.html       (A good FAQ on the
subject)
http://emporium.turnpike.net/P/PDHA/health.htm  (IAOMT's web page)
http://home.sol.no/reiersol/amalgam.htm	        (Recent amalgam
research)
http://vest.gu.se/~bosse/MercuryPage.html       (Mercury page)
http://www.tiac.net/users/mgold/dental/dental.html (Golds page)
http://www.hwc.ca/dataehd/English/mdb/r&s/amalgam_position.htm
(health-canada statement)
http://www.teleport.com/~ctseng/cfs.html        (Jeff clarks
CFS/Amalgam page)
http://203.23.131.20/wholmed/lphs18.htm         (Amalgam in your
teeth)
http://www.2cowherd.net/q/                      (DaveQ's MS page)
http://www.bioprobe.com                         (Bioprobe - books on
amalgam,data..)
http://www.envprevhealthctratl.com/merc_tox.htm (Dr Edelsons Mercury
advice page)
http://www.web-maker.com/dentists/dentists.htm  (John Hogans site)
http://www.selene.com/healthlink/amalgam.html   (Rethinking Amalgam
Safety)
http://www.unpronounceable.com/amalgam/index.html (Crusade against
amalgam)
http://www.dental-revision.org/cover.htm        (Discussion of Amalgam
Hazards..)
http://www.isl.net/~hoffcomp/amalgam.html       (Kip Sullivans text)
http://rtgsun.rtg.ofa.ki.se/forodont/amalgam1.htm  (Research
Amalgam-Immune system link)
http://www.fplc.edu/risk/vol2/spring/royal.htm  (Mike Royals Amalgam
page)
http://www.doubleclickd.com/ltexpo96/source/fillings.html (Dr Parks
page)
http://www.medmarket.com/tenants/reiddds/herbplus/info/levin3.html (Dr
Levins text)
http://www.community-care.org.uk/ME/behan1.html  (Prof Behans report
on ME-toxin link?)
http://www.sukel.com/fillings.htm               (Dr Phillip Sukel DDS
- "The silver filling controversy - pro & cons..)
http://mars.execulink.com/~manager/fuartcl4.htm (Is Amalgam Safe?)
http://www.all-natural.com/merceff1.html        (Biological fx of Hg
from Amalgams)
http://www.waterinfo.com/amalgam.HTM            (Hg pollution from
Dental Practice wastewater)
http://main.chem.ohiou.edu/~chem330/tox330_2.html (Good article of
toxins - inc Amalgam/Mercury)
http://www.moreton.com.au/ana/handbook/amalgam.htm (access n Able -
Australian Health site)
http://www.isl.net/~hoffcomp/monjourn.html      (Shirleys personal
struggle with Alzheimers, possible Hg link?)
http://alt.venus.co.uk/hypermail/markthomas/3380.html (Panorama
documentary complete text)
http://alt.venus.co.uk/hypermail/markthomas/3832.html (Tuebingen
study)

To learn more about the Amalgam safety issue (or lack of) visit:-
  http://ourworld.compuserve.com/homepages/pcsol




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