Thiols in catalase and SOD

Chuck Miller rellim at MAILHOST.TCS.TULANE.EDU
Thu Apr 23 09:46:56 EST 1998


Hi Chris and others,

There are many SOD and catalase sequences entered in the electronic
databases -e.g. SwissProt, Genbank, etc., which can be searched, retrieved,
and examined for location of Cys residues. Here are a few structural
references.

Prog Biophys Mol Biol 1997;67(2-3):217-252
Structural chemistry and biology of manganese metalloenzymes.
Christianson DW
Department of Chemistry, University of Pennsylvania 19104-6323, USA

Protein Sci 1997 Feb;6(2):481-483
Crystallization and preliminary structural analysis of catalase A from
Saccharomyces cerevisiae.
Berthet S, Nykyri L, Bravo J, Mate MJ, Berthet-Colominas C, Alzari PM,
Koller F, Fita I

Protein Sci 1998 Mar;7(3):545-555
Subunit asymmetry in the three-dimensional structure of a human
CuZnSOD mutant found in familial amyotrophic lateral sclerosis.
Hart PJ, Liu H, Pellegrini M, Nersissian AM, Gralla EB, Valentine JS,
Eisenberg D
UCLA-DOE Laboratory of Structural Biology and Molecular Medicine,
University of California, Los Angeles  90095, USA.

Biochemistry 1998 Apr 7;37(14):4731-4739
Probing the active site of human manganese superoxide dismutase:
the role of glutamine 143. Hsieh Y, Guan Y, Tu C, Bratt PJ, Angerhofer A,
Lepock JR, Hickey MJ, Tainer JA, Nick HS, Silverman DN Departments of
Pharmacology and Therapeutics, Biochemistry and Molecular Biology, and
Chemistry, University of Florida, Gainesville, Florida 32610, Department of
Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines
R.

J Mol Biol 1997 Dec 5;274(3):408-420
Unique structural features of the monomeric Cu,Zn superoxide
dismutase from Escherichia coli, revealed by X-ray crystallography.
Pesce A, Capasso C, Battistoni A, Folcarelli S, Rotilio G, Desideri A,
Bolognesi M
Dipartimento di Fisica and INFM, Universita' di Genova, Largo Rosanna
Benzi, 10, 16132 Genova, Italy.

Am J Respir Cell Mol Biol 1997 Oct;17(4):393-403
Mouse extracellular superoxide dismutase: primary structure,
tissue-specific gene expression, chromosomal localization, and lung
in situ hybridization. Folz RJ, Guan J, Seldin MF, Oury TD, Enghild JJ, Crapo JD
Department of Medicine, Duke University Medical Center, Durham, North
Carolina 27710, USA.


Best of results,
Chuck

Dr. Charles A. Miller, III,   rellim at mailhost.tcs.tulane.edu
Bionet.toxicology newsgroup: http://www.bio.net/hypermail/TOXICOLOGY
Dept. Environmental Health Sciences, SL29
Tulane-Xavier Center for Bioenvironmental Research and
Tulane Univ. School of Public Health and Tropical Medicine
1430 Tulane Ave.
New Orleans, LA 70112
(504)585-6942, fax (504)584-1726





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